Head and neck cancer

 

What is head and neck cancer?
 

Around 90% of head and neck cancers begin in the squamous cells that line the moist, mucosal surfaces inside this region of the body, such as those inside the mouth, nose and throat.1

Where does head and neck cancer occur?2,3


Prevalence of head and neck cancer

Head and neck cancer is the 7th most common cancer in the UK with around 13,800 new cases diagnosed each year.4 There are around 4,900 head and neck cancer deaths in the UK every year and, over the last decade, the mortality rates of head and neck cancer have increased by around a sixth (18%) in the UK.4

Signs and symptoms of head and neck cancer

The table below includes some common symptoms for the different types of head and neck cancer, which vary depending on where the cancer is located and whether it has spread to nearby tissues.1 It is important to remember that someone may not necessarily have head and neck cancer if they are experiencing some of these symptoms, but it is advised to monitor them and speak to a healthcare professional if they do not improve.

Cancer site Possible symptoms
Mouth5
  • A sore on the lip or in the mouth that doesn't heal
  • Unexplained, persistent lumps in your mouth
  • Loosening or pain of the teeth
Voice box (laryngeal)6
  • Persistent hoarseness
  • Difficulty or pain swallowing
  • Noisy breathing
  • Shortness of breath
  • Persistent cough
  • Lump or swelling in the neck
Throat5
  • Lump in the neck or back of throat
  • Persistent sore throat
  • Difficulty chewing or swallowing
  • Ear pain or ringing in the ears
Salivary gland7
  • Numbness in part of your face and drooping on one side of your face
  • Lump or swelling on or near the jaw, or in the mouth or neck
Nasal and sinus8
  • Persistent blocked nose, which usually only affects one side
  • Nosebleeds
  • Decreased sense of smell
  • Mucus running from the nose or down the throat
Back of the nose and mouth (nasopharyngeal)9
  • A lump in the neck, due to the cancer spreading to the lymph nodes (small glands that are part of the immune system) in the neck
  • A blocked or stuffy nose
  • Nosebleeds
  • Hearing loss (usually only in one ear)

 

Head and neck cancer symptoms5-9


Treatment options for head and neck cancer

 

People with head and neck cancer are usually treated in specialist centres by a team of healthcare professionals. Treatment options are dependent on the type and stage of their cancer but may include:10

Surgery

Radiotherapy

Chemotherapy

Targeted therapy

Immunotherapy


The unmet needs of head and neck cancer patients
 

The quality of life of head and neck cancer patients and their treatment outcomes are affected by various factors, from the disease itself, to the treatment side effects, to the wide range of mental health issues associated with the diagnosis. Head and neck cancer treatment often have profound impacts on the  patients' professional lives. Many patients have to reduce their working hours or take temporary leave, sometimes indefinitely. Even when willing and able to return to work, they may face workplace discrimination due to their diagnosis. The resulting economic and psychological pressure negatively affect the patients' mental health, heighten symptom severity perception and hinder access to rehabilitation treatments, impacting recovery and quality of life.11


References

1 Heroiu Cataloiu AD, et al. Multiple cancers of the head and neck. Maedica (Bucur). 2013 Mar;8(1):80-5.

2 World Cancer Research Fund. Head and Neck Cancers. Available at: https://www.wcrf.org/preventing-cancer/cancer-types/head-and-neck-cancer/
Last accessed: August 2026

3 Cancer Research UK. Head and neck cancer. Available at: https://www.cancerresearchuk.org/about-cancer/head-neck-cancer
Last accessed: August 2026

4 Cancer Research UK. Head and neck cancers statistics. Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/head-and-neck-cancers#heading-Zero
Last accessed: August 2026

5American Cancer Society. Signs and Symptoms of Oral Cavity and Oropharyngeal Cancer. Available at: https://www.cancer.org/cancer/types/oral-cavity-and-oropharyngeal-cancer/detection-diagnosis-staging/signs-symptoms.html.
Last accessed: August 2026

6 Macmillan Cancer Support. Signs and symptoms of laryngeal (larynx) cancer. Available at: https://www.macmillan.org.uk/cancer-information-and-support/laryngeal-larynx-cancer/signs-and-symptoms.
Last Accessed: August 2026

7 Mayo Clinic. Salivary gland tumors. Available at: https://www.mayoclinic.org/diseases-conditions/salivary-gland-cancer/symptoms-causes/syc-20354151.
Last accessed: August 2026

8 NHS Inform. Nasal and sinus cancer. Available at: https://www.nhsinform.scot/illnesses-and-conditions/cancer/cancer-types-in-adults/nasal-and-sinus-cancer/.
Last accessed: August 2026

9 Mayo Clinic. Nasopharyngeal carcinoma. Available at: https://www.mayoclinic.org/diseases-conditions/nasopharyngeal-carcinoma/symptoms-causes/syc-20375529.
Last accessed: August 2026

10 The Royal Marsden. Common misconceptions of head and neck cancers. Available at: https://www.royalmarsden.nhs.uk/private-care/news-and-blogs/common-misconceptions-head-and-neck-cancers.
Last accessed: August 2026

11 Lin L, et al. Surviving and thriving: Assessing quality of life and psychosocial interventions in mental health of head and neck cancer patients. Asian Journal of Surgery. 2024 Nov 28; https://doi.org/10.1016/j.asjsur.2024.11.048
Last accessed: August 2026

August 2026 | ONC-GB-2600213